Dysregulation of the ubiquitin-proteasome system (UPS) leads to the accumulation of aggregationprone proteins which has been linked to neurodegeneration and cancer. The 26S proteasome is acentral component of the UPS. It assembles by the successive recruitment of the 33 different proteasome subunits which is assisted by proteasome assembly chaperones: five for the CP and five for the RP. RPAC…
Cumulative evidence has shown that the alteration of mechanical and frictional forces composed of pulsatile and flow shear stress in the aorta plays a significant role in the abdominal aortic aneurysm (AAA). Altered hemodynamics in AAA with its subsequent sac expansion and rupture are a consequence of various immune cells interaction and crosstalk with vascular cells within the AAA sac. The…