Colorectal cancer (CRC) ranks third in cancer incidence and cancer-related mortalities worldwide. The transformation of normal colon and rectal cells to malignant adenocarcinomas due to unrepaired DNA damage which leads to oncogenic mutations. These mutations also increase the frequency of DNA damage, leading to endogenous replication stress (RS). This introduces an opportunity to induce sy…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis, being commonly diagnosed in the unresectable advanced or metastatic stage which poses an extremely poor prognosis for patients. Hypoxia predominates most pancreatic cancer tumour microenvironments (TME), with HIF-1 signalling being overexpressed in 88% of all pancreatic cancers. Long noncoding RNAs (lncRNAs) have emerge…