Pooled Whole-genome CRISPR/Cas12a Loss-of-Function Screens Reveal A Novel Pre…

Though rare, atypical teratoid/rhabdoid tumors (ATRT) remain a clinically challenging pediatric tumor and lack defined treatments. “One-size-fits-all” multimodal regimens have largely been of modest clinical benefits thereby urging the development of precision medicine for ATRT. However, the single- mutation nature of pediatric tumors like ATRT has misrepresented the potential of non-mut…

POOLED WHOLE-GENOME CRISPR/CAS12A LOSS-OF-FUNCTION SCREENS REVEAL A NOVEL PRE…

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BM 24-028

Novel High Throughput Drug Screening Reveals Therapeutic Opportunities for Pe…

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric CNS tumor yet lacking standardized therapies while current management standards are not of significant clinical benefit. With the opportunity of accessing the Childhood Cancer Model Atlas (CCMA)’s vast pediatric cancer resources, high-throughput drug screening (HTS) was carried out on the CCMA’s ATRT cohort against the novel…