As one of the defense mechanisms of the body, inflammation has both beneficial and detrimental roles to the body. Inflammation Is a process involving the immune system to eliminate harmful substances that invade the body, thus beginning the healing process. Inflammation could also cause several detrimental effects, such as tissue injury and protein denaturation, which increases vascular permeab…
Cancer is one of the leading causes of death in 2018. Two of the most common cancers are breast cancer and colorectal cancer with the incidence of 11.6% and 10.2%, respectively. The current treatments of cancers are limited to surgery, chemotherapy, radiotherapy, and targeted therapy. However, these treatments could induce cell resistance and some of them, notably chemotherapy and radiotherapy…
Metabolic Syndrome (MetS) is a cluster of risk factors that may result to the development of Non-Communicable Diseases (NCDs) and economic losses. It has been suggested that weight loss program may prevent or reduce the incidence of MetS. However, there are numerous factors that may affect the success of a weight loss program, such as age, gender, and knowledge. This study investigates the weig…
Recent spike of focus towards plant-based medicines has prompted the search for alternatives to commercialized drugs, namely anti-inflammatory medications. Laportea decumana (daun gatal) is a plant native to Papua, whose leaves have been traditionally used as pain remedies. Due to its effect bearing resemblance to classical anti-inflammatory drugs, the need to investigate this phenomenon is sup…
Single-cell live imaging is a powerful method to investigate cell motion. Using this approach, Nanba and colleagues have elegantly demonstrated that motion can predict human epidermal keratinocyte (NHEKs) stem cell fate (Nanba et al., J. Cell Biol., 2015). Human thymus, a primary lymphoid organ, contains numerous TP63+/EpCAM+ epithelial cells (hTECs) that are cl…
The primary cilia has been found to be a key organelle for various cell signal transduction pathway, such as Hedgehog, wnt, and Notch pathway. Due to this reason, the primary cilia has an increased interest of research. The defects of primary cilia are usually referred to as ciliopathy, which will result in the disorder in the development of the cell. Some of the lethal syndrome is caused by th…