LipY is a gene product from Mycobacterium tuberculosis that plays an important role in the hydrolysis of triacylglycerol (TAG), especially during the dormant stage. LipY is one of the PE family protein which are involved in immune pathogenicity and virulence of mycobacteria. The PE domain of LipY participates in the modulation of LipY activity. LipY protein devoid of its PE-domain (LipYΔPE) e…