Ubiquitination is a post translational modification (PTM) process that plays a role in protein degradation by the addition of ubiquitin groups to target protein. In the ubiquitination process, E3 ubiquitin ligase is responsible to mediate the bridge between E2 ubiquitin-conjugating enzymes and substrate for ubiquitin conjugation. Pellino1 or PELI1, one of the ubiquitin ligases, was found to …
Coronavirus disease 2019 (COVID-19) is an infectious disease which has become an emerging global health crisis. However, there is still less of the natural bioactive compound used for curing COVID-19. Flavonoid is a natural product that has a specific effect in treating viral infection. Flavonoid also can be used to treat COVID-19 due to its specific mechanism to inhibit the activity of 3C-like…