Thesis

Encapsulation of Moringa Oleifera Extract into Niosomes for anti-aging treatment

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Aging is associated with the accumulation of free radicals in the skin. Ascorbic acid is a potent antioxidant that is often used in cosmetic formulations to combat the effects of free radicals. Recently, the cosmetic industry has shifted toward natural products. One that has been gaining attention due to their versatility is drumstick tree or Moringa oleifera. The problem with the extract is their poor penetration. Elucidation of whether Moringa oleifera extract has a superior antioxidant potential than ascorbic acid and their subsequent encapsulation in lecithin-span 80 niosomes are the objectives of this study. This was done through total phenol and flavonoid content, DPPH testing, cytotoxicity and cytoprotective effect on 3T3 mouse fibroblasts with free radical insult. Characterization of niosomes include pH test, particle size, and zeta potential, then finally penetration testing with Franz cell diffusion. The IC50 of antioxidant activity of the extract through DPPH assay was 24.69 ± 1.89 ppm and IC50 of ascorbic acid was found to be 5.216 ± 1.85 ppm. The extract was found to be less cytotoxic and more cytoprotective than ascorbic acid observed in vitro. The formulation chosen to encapsulate the extract (lecithin:span 80 in 170:30mg) successfully enhanced the stability and penetration up to two-folds at the 6th hour. In conclusion, Moringa oleifera extract possessed a superior antioxidant ability and their encapsulation into niosomes enhanced their stability and penetration through the skin.

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Detail Information

Series Title

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Call Number

PHA 21-005

Publisher

: i3L, Jakarta., 2021

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Aging
Ascorbic acid
cosmetic formulations
Moringa oleifera extract

Specific Detail Info

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Statement of Responsibility

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