Thesis

EVALUATION OF ANTI-ALZHEIMER ‘S ACTIVITY OF CORIANDER (CORIANDRUM SATIVUM L.) USING NOR TEST AND GENE EXPRESSION OF BDNF & CREB1

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"The most contributed neurodegenerative disease in dementia, Alzheimer’s disease (AD), has
affected more than 26 million people in 2006 and is predicted to increase in quadruplicate in 2050.
The etiology of the disease remained unclear until now, but it is suggested to be arisen by multiple
factors. AD patients have experienced impaired cholinergic activities related to memory and cognitive
function. The cholinergic hypothesis is one of the theories explained in AD pathogenesis and becomes
the target for therapeutic agents, like donepezil. Nevertheless, the available therapeutic agents are
unable to stop or prevent the disease. Previous studies of the well-known herbs Coriander sativum L.
(coriander) suggested the biological activities within the leaves are able to provide anti-Alzheimer’s
activity. In the present study, an in-vivo study with a scopolamine-induced memory impairment mice
model is used to assess the anti-Alzheimer’s activity within various coriander leaves extract
concentration (200, 400, 600 mg/kg) given in 10 days. The anti-Alzheimer’s activity is evaluated
through novel object recognition (NOR) and gene expression of CREB1 and BDNF. Novelty preference
was shown in mice treated with all concentrations of coriander leaves extract after induced memory
impairment by scopolamine, where the administration of 200 mg/kg, 400 mg/kg, and 600 mg/kg of
the extract resulted in a preference of 57.03% (p

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Availability

Detail Information

Series Title

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Call Number

BM 21-005

Publisher

Jakarta : i3L, Jakarta., 2021

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Alzheimer’s Disease
anti- Alzheimer’s activity
Coriandrum sativum L.
Novel Object Recognition (NOR)

Specific Detail Info

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Statement of Responsibility

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