Thesis

Screening Phytochemicals for Regulation of Gene Expression in Breast Cancer

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Breast cancer is the most common cancer in woman and the second leading cause of cancer deaths in the world among women. Research have shown the efiicacy of phytochecmicals as asupplementary treatment in breast cancer through the regulation of gene and microRNA (miRNA) expression. This study aims to identify differentially expressed miRNA-gene pairs in breast cancer across different stages in order to identify diagnostic and prognostic biomarkers using data retrieved from The Cancer Genome Atlas (TCGA). The data will undergo statistical and correlation analysis to identify differentially expressed miRNAs and genes and the subsequent pairs. Results were confirmed bt matching against miRNA databases: miRTarBase and miRDB. Molecular docking with the phytochemicals as ligands and differentially expressed genes as receptors was then conducted.

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Availability

Detail Information

Series Title

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Call Number

BI- 21 004

Publisher

i3L, Jakarta : i3L, Jakarta., 2021

Collation

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Language

English

ISBN/ISSN

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Classification

BI- 21 004

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Breast--Cancer--Prevention.
phytochemicals
TCGA

Specific Detail Info

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Statement of Responsibility

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