Thesis

In Vivo Diabetic Wound Healing Evaluation of Biocellulose Black Tamanu Oil Hydrogel

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Diabetes mellitus is one of the most prevalent diseases; with an estimated 422 million cases
worldwide. A general cause of blindness, heart attacks, stroke, kidney failure and amputation of the
lower limbs. Diabetes mellitus is one of the major causes of impaired wound healing. Furthermore,
open wounds in diabetic individuals can be life threatening as it can act as a way for bacteria to enter
the body that may lead to a range of complications. An active compound present in tamanu is
Callophyllolide, the main benefit it possesses is the ability to decrease production of
proinflammatory cytokines and increase anti-inflammatory cytokines. Tamanu oil also exhibits a high
antibacterial activity against pathogens involved in dermal infections. Recently, biocellulose has been
implemented for several utilizations including wound dressing. Properties of biocellulose include high
water uptake capacity and permeability that produces a favorable environment for fast tissue
regeneration, pain reduction and prevent infection during the wound healing process. This research
project entails the wound healing evaluation in diabetic induced mice using biocellulose dark tamanu
oil hydrogel matrix. Antimicrobial test demonstrates the antimicrobial activity of tamanu while
qualitative and quantitative wound measurement and additionally in the histology results shows the
most prominent wound healing process was in the BC-Tamanu group. The importance of this study is
a way to speed up the healing time in diabetic patients as they possess a lower healing process due
to a result of a poor immune system activation.
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Availability

Detail Information

Series Title

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Call Number

BM 22-021

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Diabetes mellitus
BC-Tamanu
Antimicrobial test

Specific Detail Info

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Statement of Responsibility

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