Thesis

Overview of Botulinum Toxin Type A and Plant-Based Compounds as a Treatment for Keloids: A Systematic Review and Meta-Analysis

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Keloids are pathological scars that arise from abnormal wound healing. The development of
keloids are caused by the over-proliferative behavior of dermal fibroblasts and the suppression of its
apoptosis. Botulinum toxin (BTX), produced by Clostridium botulinum, is able to suppress scar
formation and regulate fibroblastic activity - therefore being a highly preferred choice for treatment
of keloids. Plant-based compounds are getting more recognized in the keloid treatment setting as
they are naturally-produced without the requirement of man-made interference. Numerous
research have also proven that plant-based compounds have a promising impact towards
therapeutic use. While the molecular mechanism of keloid is still not fully understood, several
components of it have been extensively investigated such as TGF-β1, α-SMA, type I collagen and
type III collagen. Botulinum toxin type A and plant-based compounds have been found to directly
interfere with these in the signaling cascades of the wound healing process.

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Availability

Detail Information

Series Title

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Call Number

BM 22-026

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Keloids
Botulinum toxin (BTX)
wound healing process
Botulinum toxin type A

Specific Detail Info

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Statement of Responsibility

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Other version/related

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