Thesis

In vivo diabetic wound healing evaluation of KBC black tamanu oil hydrogels

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Diabetes is a major epidemic in nearly all regions of the world. Roughly 15% of diabetic patients will
develop chronic wounds and eventually diabetic foot ulcers in their lifetime. These chronic wounds
exhibit delayed wound closure and may become fatal if left untreated. One of the promising
treatments and management for diabetic foot ulcers is applying appropriate dressing materials.
Hydrogels are among the best candidates because they can maintain a moist environment ideal for
tissue regeneration and growth. This study uses keratin, bacterial cellulose, and tamanu oils as the
potential novel matrix for chronic wound healing. Keratin is extracted from human hair using the
Shindai method, while bacterial cellulose is made from Komagataeibacter intermedius isolated from
kombucha drinks. Black tamanu oil was obtained commercially and applied to the wounds to suppress
the microbial growth on the wound site. Mice were first introduced to streptozotocin to induce
diabetes for ten days, and the dorsal subcutaneous model was made by piercing the skin with a biopsy
punch. Results show that the matrix KBC improves tissue regeneration while adding tamanu oil to the
matrix significantly improves tissue regeneration and remodeling.

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Availability

Detail Information

Series Title

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Call Number

BM 22-031

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Calophyllum inophyllum oil
Wound healing
in vivo study
diabetic ulcer
bacterial cellulose

Specific Detail Info

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Statement of Responsibility

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