Thesis

In vitro Percutaneous Absorption Study of Glycols as Penetration Enhancers towards Niacinamide against Skin Models

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Cosmetics have been widely used to improve the skin condition. Niacinamide is known as the
vitamin B3 which works to repair the skin condition. Unfortunately, It has a limited ability to penetrate
the skin. Therefore, a penetration enhancers is important to be conducted to ensure an adequate activity
of the active ingredients. Several types of glycols were tested and expected that the difference of
chemical properties of glycols are associated with the ability of binding affinity and the lipophilicity of
the API as well as the humectants. Few types of penetration enhancers will be tested against the
reconstructed human epidermis, pig ear skin, and artificial membrane to compare the penetration
enhancer activity towards the skin and compare the penetration profile of each skin membrane. The
experiment will be conducted by utilizing the MatTek Permeation Device (MPD). The results showed that
the effect of addition of glycerin and the different length of carbon chain and different placement of the
-OH group significantly affect the cumulative drug release and average flux of the API. However, the
different concentration to dose response of glycols added did not significantly affect the release of the
drug due to its viscosity. It was shown that different membranes significantly affect the penetration
profile of the active ingredients.

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Availability

Detail Information

Series Title

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Call Number

PHA 22-001

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Niacinamide
Penetration Enhancers
Glycols
Membrane
Cumulative Drug Release
Average Flux
MatTek Permeation Device (MPD)

Specific Detail Info

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Statement of Responsibility

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