Thesis

Systematic Review on Advances of Therapeutic Gene Therapy Against Prostate Cancer

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Prostate cancer is commonly found among men above 65 years old, making it one of the most commonly found malignancies found worldwide. Prostate cancer lacks early signs or symptoms, making it hard to diagnose in the early stages. The late-stage diagnosis tendencies accompanied by the inherent resistance mutation capability of cancer make it a hard disease to cure. Recently advancements in the medical field regarding gene therapy held a promise in curing this disease. Gene therapy utilizes gene manipulation to exert therapeutic effects on genetic diseases, including prostate cancer. With a method of delivery using viral and nonviral vectors, gene therapy held a significant advantage over conventional cancer treatments by eliminating the possibilities such as drug resistance and reduced side effects. This Systematic Review aims to provide the latest information regarding gene therapy as a therapeutic measure for prostate cancer and identify gaps in current treatment that can be mitigated by using gene therapy. From open databases provided in online spaces like NCBI, Elsevier, and PubMed, 74 journals were selected, where only 17 journals passed the title and abstract screening, full-text review, and bias assessment. The results were grouped based on the mechanism of action of each gene therapy measure explained in the journals. In this review, four main strategies involving gene therapy are explored for their potential as the means of treatment against prostate cancer. The first strategy is immunomodulatory gene therapy using CAR T-cell. The second is Oncolytic virotherapy, and armed oncolytic virus. The third strategy is genetic alteration using mRNA, siRNA, Corrective gene therapy, and suicide gene. The last strategy is a novel strategy using CRISPR/Cas-9 and Telomerase targeting therapy. In this review, qualitative data regarding different gene therapy strategies are elaborated, yet more robust quantitative data is needed to strengthen the reasoning for the use of these gene therapy measures for the general population.

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Availability

Detail Information

Series Title

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Call Number

BM 22-046

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Gene Therapy
Prostate Cancer
Gene Editing tools
Viral vector
Nonviral vector
CRISPR/Cas-9
Car T-cell
mRNA
siRNA
Corrective Gene Therapy
Suicide Gene Therapy
Telomerase Targeting Therapy

Specific Detail Info

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Statement of Responsibility

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