Thesis

Lipoprotein Lipase and Cholesteryl Ester Transfer Protein Genes-Dietary Fat Interactions on Lipid Trait: A Nutrigenetic Update in Asian Indians

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India has the second-highest type 2 diabetes mellitus (T2DM) due to the South Asian phenotype,
poor lipid profile, and unbalanced dietary pattern. Evidence has been discovered that single
nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) and cholesteryl ester transfer protein
(CETP) genes are linked to differences in lipid levels in response to dietary intake. Hence, this review
aimed to explore and present nutrigenetic studies of LPL and CETP SNPs and dietary interactions on
lipid traits among Asian Indians. Relevant articles were retrieved through PubMed and Google
Scholar up until March 2022. The LPL & CETP SNPs as exposure, dietary and lipid phenotype as
outcome variables, and conducted in the Asian Indian population were the inclusion criteria.
Forty-seven articles for eligible criteria were screened into 12 full-text qualified studies: nine
associations and three interaction studies. CETP TaqIB and rs1800775, LPL rs320 and S447X were
consistently associated with HDL and TG levels. Overall, LPL & CETP SNPs x dietary interaction studies
on Asian Indians have not been thoroughly conducted. To date, only three studies investigated
different quantities of dietary fat on four SNPs: LPL rs1121923 and rs4922115 on HDL-C and TG
levels, respectively; CETP rs3764261 on LDL-C and total cholesterol; and CETP TaqIB on HDL-C. It is
suggested for each individual to obtain healthy dietary fats that take into account various types of fat
and total energy intake. The ideal prediction model for each person’s nutritional needs must
therefore be designed utilizing machine learning and an integrated artificial intelligence approach.

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Availability

Detail Information

Series Title

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Call Number

FSN 22-020

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

lipoprotein lipase
cholesteryl ester transfer protein
dietary fat
lipids
nutrigenetics
Asian Indians

Specific Detail Info

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Statement of Responsibility

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