Internship Report

Epstein-Barr Virus-Related IgA Antibodies Detection Using ELISA-Based Assay for The Early Diagnosis of Nasopharyngeal Carcinoma in Dharmais Cancer Hospital

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Nasopharyngeal carcinoma (NPC) is the fourth most frequent tumor after skin, breast, and
cervical cancer in Indonesia (Adham et al., 2012). The majority of NPC patients receive a late diagnosis
since the disease's early symptoms are non-specific. Therefore, a biomarker is needed to detect NPC
early. Interestingly, NPC onset and progression are highly correlated with Epstein-Bar Virus (EBV)
infection. Moreover, compared to healthy individuals and patients with other head and neck
disorders, individuals with NPC have higher levels of anti-Epstein-Barr virus (EBV) antibodies,
particularly immunoglobulin A (IgA). This study aimed to observe and assess the utilization of ELISA
method in Dharmais Cancer Hospital for the detection of EBV infection-related antibodies as a way for
early NPC diagnosis. As well as to observe the relationship between age group and gender with EBV
seroprevalence of patients. In this study, 51 NPC suspected patients with symptoms undergo the
detection of three EBV-associated antibodies using ELISA. This study found that older patients had
significantly higher seroprevalence and frequent symptom rates than younger people. Among all
antibodies, Anti-EBNA-IgA was found to be the most frequent in all NPC suspected patients. Based on
gender, male patients were found to be more susceptible to NPC compared to female.

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Detail Information

Series Title

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Call Number

BM 22-021

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ELISA
Nasopharyngeal Carcinoma
Epstein-Barr Virus

Specific Detail Info

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Statement of Responsibility

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