Internship Report

The Evaluation of Anticancer Capabilities of Marchantia paleacea Extracts

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ancer is a major burden in the healthcare system, as the leading disease in terms of DALYs
(Disability-Adjusted Life Years) afflicted to the patient, and second in terms of mortality rate. Until
this day, there is still no permanent universal cure for cancer, with current treatments either capable
of afflicting adverse side effects to the patient, or relying on several different mechanisms
susceptible to alterations by the cancer cell or its surrounding environment. Alternative compounds
would need to be screened to find potentially effective anticancer agents. Phytochemicals have a
great potential for anticancer properties, as shown by the presence of plant-based cancer drugs
already used in the market. Being one of the 17 megadiverse countries, Indonesia possesses an
abundance in potential plants to screen for possible anticancer phytochemicals. Marchantia
paleacea, a type of liverwort present in Indonesia, would possibly be one of these anticancer
compounds due to the presence of compound families previously already exerting anticancer
properties. To evaluate whether or not M. paleacea extracts possess anticancer capabilities,
M.paleacea were extracted through an ethanol-based maceration method, then MTT and colony
forming assays were performed. Even though the experiment conditions were not optimal, the M.
paleacea extract did not exert any cytotoxic effects on the normal (HaCaT) and cancerous (HT-29) cell
lines, in contrast with the positive control 5-FU.

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Availability

Detail Information

Series Title

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Call Number

BM 22-031

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Cancer
HaCaT
Disability-Adjusted Life Years
Marchantia paleacea

Specific Detail Info

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Statement of Responsibility

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