Report

IN VITRO STUDY OF MARCHANTIA PALEACEA POTENTIAL AS CYTOPROTECTIVE AGENTS ON HACAT CELL LINES UNDER OXIDATIVE STRESS

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In this study, the potential of Marchantia paleacea, a bryophyte that grows in the Cibodas
Botanical Garden, was studied for its cytoprotective capability against oxidative stress. H
was used. Although bryophytes have been used in traditional medicine for centuries, this group of plants
is still poorly studied. Bryophytes have been shown to contain metabolites such as flavonoids,
polyphenols, alkaloids, and saponins that can be used as anti-aging agents due to their anti-
inflammatory effects. It was hypothesized that M. paleacea may have anti-aging properties that can
be used as a cytoprotective agent against oxidative stress. To test the cytoprotective effect of M.
paleacea, MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-
tetrazolium) assay was used. To induce the oxidative stress, hydrogen peroxide (H
) was used in
this study. The results show that M. paleacea extracts may have cytoprotective effects against H
at 22 ppm. However, further study and validation was still needed to validate the biological
significance of the results.

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Availability

Detail Information

Series Title

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Call Number

EP BT008

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Cytotoxic
M. paleacea
MTS
cytoprotective

Specific Detail Info

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Statement of Responsibility

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