Thesis

Preliminary Study of Long Non-Coding RNA(s) (LncRNA) and Their Utility For Racial Differences Biomakers in Prostate Cancer

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Prostate cancer (PC) is a heterogeneous disease that has a slow progression compared to other
types of cancers, where the severity of prostate cancer commonly increases along the age of each
individual. PC is still considered as a global disease and its development is affected by racial differences.
African-American (AA) men are proven to be more susceptible to PC compared to European-American.
Currently, lncRNA is widely identified as biomarkers that is suitable for cancers, including PC. In this
study, the RNA-Sequencing analysis such as RNA-Alignment using STAR, Differential expression
analysis, and the network analysis were run in order to search for the potential lncRNA(s) that might
able to be developed as a biomarker for racial differences in PC. There were top 10 lncRNA(s) found, 7
of which were lncRNA(s) that had not been detected in context of PC but had been previously detected
in other organs includes, LINC01001, AC098617.1, AC005863.1, CALML3−AS1, LINC01087, AC064834.1,
and LINC00958, where it was found that LINC01001 had the most interaction with a total of 30 target
genes. Meanwhile, the rest of the lncRNA(s) found were LINC00261, F11−AS1 and PCA3 which had
been previously detected in PC and other body parts. Therefore, it was known that there were
lncRNA(s) useful for further development as biomarkers for racial differences in PC patients of AA
descent. However, further in vitro analysis validation is still needed to ensure the validity of these top
10 identified lncRNA(s) as PC biomarkers, especially in the context of racial differences.

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Availability

Detail Information

Series Title

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Call Number

BI 23-004

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Prostate Cancer
Differential Expression analysis
Long non-coding RNA (lncRNA)
Racial Differences
RNA-Sequencing

Specific Detail Info

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Statement of Responsibility

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