Thesis

Resveratrol and Levofloxacin Loaded 3D Printed Mucosal Wound Dressing

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Mucosal wound is a wound that appears in the mucosal ssue that can be caused by a variety of
factors, such as medicaon, environmental factors, microbiota and genec factors. Incorporang
resveratrol and levofloxacin in ethyl cellulose can create a wound dressing that has good
thermostability and durability. Resveratrol was found to have an-inflammatory properes that have
the ability to enhance the wound healing process. Levofloxacin is also added to the formulaon as it
has anbacterial properes that are effecve against gram posive and gram negave bacteria.
Gantrez AN 119 BF can also be used for the mucoadhesive properes to make the wound dressing
scks to the mucosal ssue. 3D prinng is used to make the wound dressing. The dressing's
physicochemical , mucoadhesive, and drug release properes were evaluated by using digital
microscope, SEM, Raman Microscopy, FTIR, DSC, TGA, mucoadhesive test, and in vitro drug release.
There are no new peaks found in the FTIR result indicang that there are no chemical interacons
happening in the formulaon. XRD and DSC analysis shows that the drug changes from crystalline
into amorphous. The TGA result shows mulple weight loss that can be caused by oxidaon of
gantrez in the reacng atmosphere. Mucoadhesive test shows that there are no significant changes
in the adhesive properes of the polymer aer the addion of the drugs. In vitro drug release shows
that the sample has burst release in the first 7 days. From the evaluaon, it can be seen that the
wound dressing has good physicochemical, mucoadhesive, drug release properes and there are no
significant changes in the mucoadhesive properes of polymer.

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Availability

Detail Information

Series Title

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Call Number

PHA 23-015

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

levofloxacin
ethyl cellulose
Gantrez
3D printed mucosal wound dressing
Resveratrol

Specific Detail Info

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Statement of Responsibility

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Other version/related

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