Thesis

Comparison of Ethyl Cellulose and Zein as Polymers to Deliver Curcumin and Levofloxacin for Wound Healing

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Curcumin (CUR) has been traditionally used as a wound healing agent, thus, is a good wound
dressing agent. To further enhance anti-bacterial prevention, levofloxacin (LEVO) is considered as it
has high effectiveness towards both gram-positive and gram-negative bacteria. CUR and LEVO are
added to ethyl cellulose (ethocel) due to its high stability towards heat, light, and chemicals. Zein is
another potential alternative to ethocel as it has anti-oxidative and anti-microbial properties thus,
increasing the efficacy of the resulting wound dressing. To enhance the elasticity and rigidness,
low-molecular-weight polycaprolactone (LPCL) was added to ethocel while glycerol was added to
zein. Semi-solid extrusion technique in 3D printing was used to decrease potential drug interaction
and negate the need for organic solvent. The printed dressings were evaluated for its
physicochemical properties, mechanical properties, and drug release capability. New peak found in
zein blank and zein drug sample at 1047 cm
-1
of FTIR analysis suggests potential chemical interaction
of zein and glycerol. XRD and DSC analysis presented peaks that prove the dressings to be
amorphous as it showed no peak and lacks peaks found in drugs, respectively. Mechanical testing
showed Young modulus of 0.4948 MPa ± 0.0194 and 0.2135 MPa ± 0.0562 for ethocel and zein,
respectively. Thus, ethocel was deemed to have lower elasticity yet higher fracture strength as
compared to zein due to its high tensile strength. In vitro drug release suggests no evidence of
polymer (ethocel and zein) effect towards the release of CUR and LEVO.

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Availability

Detail Information

Series Title

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Call Number

PHA 23-016

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

levofloxacin
ethyl cellulose
zein
Semi-solid extrusion 3D printed wound dressing

Specific Detail Info

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Statement of Responsibility

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