Thesis

Keratin Bacterial Cellulose Hydrogels with Green-Tamanu oil as Wound Dressings: In Vivo Study in Diabetic Mice Models

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Diabetes has been a worldwide growing issue with a risk of diabetic ulcers, which are chronic wounds
with impaired wound healing processes. The current wound dressing commonly used in clinical
practice, gauze, remains unsatisfactory due to its lack of exudate control, moisture provision, and risk
of re-injury during replacement of the dressing. On that account, the development of a more suitable
wound dressing has been conducted in multiple studies. The current study proposes the use of
bacterial cellulose (BC), keratin, and green-tamanu oil (GTO) as a combination treatment for diabetic
wounds in diabetic mice models. Six mice with STZ-induced diabetes were given 3 full thickness
wounds which were then treated with gauze as control, keratin bacterial cellulose (KBC), and topical
GTO combination with KBC (KBC-GT). Wounds from the KBC-GT group underwent a significantly
higher wound closure (%) on day 6 and 9 compared to control wounds. Histological observation of the
KBC-GT wound section using Masson’s Trichrome staining also displayed the thickest epidermis
generation, most dense collagen deposition, distinct presence of panniculus carnosus, and higher
amount of hair follicles formed when compared to the other wound groups. In addition, gram staining
results from samples obtained from all wound groups demonstrated the antibacterial activity of GTO
against gram-positive bacteria. These findings conveyed that KBC-GT acts as a compelling wound
treatment with a great potential in effectively treating diabetic wounds while also preventing
infection from gram-positive bacteria

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Availability

Detail Information

Series Title

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Call Number

PHA 23-008

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Wound healing
bacterial cellulose
Calophyllum inophyllum L., Keratin
Diabetic mice models

Specific Detail Info

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Statement of Responsibility

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