Thesis

Investigation of Atopic Dermatitis-related Gene Expression Levels of TNF-?- & IFN-?-induced HaCaT Treated with Calophyllum inophyllum Ethanol-immiscible Extract (EIE)

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Atopic dermatitis (AD) is a multifactorial chronic relapsing inflammatory skin disease characterized by
flares of pruritic lesions, rashes and lichenification. Skin barrier and immune barrier dysfunction,
grouped with genetic predisposition all contribute to the development of AD. Available medications with
the purpose of mitigating symptoms and exacerbations provide surface-level therapeutic effects, and can
lead to various undesirable side effects such as atrophy, stretch marks, and rosacea. Therefore current
studies in this field of research have aimed to create novel drugs using natural products to treat AD that
will yield effective results without the unwanted side effects. This study investigates the effects of C.
inophyllum ethanol-immiscible extract (EIE) on major AD-related inflammatory genes IL-33, IL-25, TSLP,
TARC, MDC, AND CTACK and skin barrier genes FLG and IVL in
TNF-α and IFN-γ -induced HaCaT, in which
EIE was shown to decrease the expression of IL-33, TLSP, MDC, and increase the expression of FLG and
IVL. Thus, there is potential for tamanu oil as a therapy for AD as it has shown to exert anti-inflammation
and skin barrier repair effects. Further studies may be done to confirm the effect of EIE on IL-25, TARC,
and CTACK.

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Availability

Detail Information

Series Title

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Call Number

BM 23-007

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Gene Expression
Calophyllum inophyllum
Atopic Dermatitis
HaCaT
Tamanu oil
alophyllum inophyllum
ethanol-immiscible extract

Specific Detail Info

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Statement of Responsibility

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