Thesis

Subchronic toxicity Study of Foeniculum Vulgare extract in Mice (Mus Musculus)

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Herbal medicines are often used as therapeutic agents and contains one or multiple active
compounds such as alkaloids, phenolics, and flavonoids. Flavonoids are natural compounds which
are essential for pharmacological activity of plants and are known for antioxidant, antibacterial, and
antiviral properties. As antiviral properties, Juglanin and quercetin are known to inhibit COVID-19
replication like 3CLPro. Foeniculum vulgare extract, known to contain juglanin and quercetin, were
found to be potential as COVID-19 treatment alternative. However, safety evaluations such as
subchronic toxicity studies are required to register F. vulgareas standardized herbal medicine. This
research aims to investigate the safety of fennel extract through sub chronic toxicity study. Extract
was administered for 90 days to mice with dose 100, 500, and 1000 mg/kg. Parameters include 28points
neuroscore behavioral assay, gross pathology, organ index, histopathology, and body weight
data were evaluated to assess the subchronic toxicity of fennel extract. The highest number of
lethality observed in the 1000 mg/kg treated mice reached 60% and the same dose was found to
potentially cause irreversible toxicity. However, lethality as high as 80% was also observed in the
control group . The other doses,100 mg/kg and 500 mg/kg caused 20% of mortality. In conclusion,
100 mg/kg, 500 mg/kg, and 1000 mg/kg Fennel extract have the potential to induce toxic effects in
repeated exposure. Another subchronic toxicity study with a bigger sample size according to BPOM
and conducting blood evaluation such as biochemical and hematology assay is recommended to
confirm and validate the toxicity effect in Foeniculum vulgare.

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Availability

Detail Information

Series Title

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Call Number

BM 23-013

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Foeniculum vulgare
Toxicity study
Subchronic
CMC-Na
Satellite treatment

Specific Detail Info

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Statement of Responsibility

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