Proceedings

The Use of Keratin-Biocellulose Black Tamanu Oil Hydrogels as A Novel Wound Dressings with Antibacterial Properties for Diabetic Ulcers in Mouse Models

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Diabetes mellitus is a global health issue that is gaining traction in our healthcare system which leads to impaired wound healing and results in chronic ulcers, these increases the risk of amputation and disease mortality rate by 50-59% in 2020. Therefore, better inventions to treat diabetic ulcers are required. A bio-cellulose hydrogel is a form of wound dressing that can aid in protecting the wound from foreign particles and maintain the humid environment of the wound. Bio-cellulose is frequently combined with other ingredients to accelerate wound healing, such as black tamanu oil and keratin. The addition of keratin has the potential to activate the keratinocyte in the healing process. Besides, black tamanu oil (Calophyllum inophyllum) is known to have anti-inflammatory and anti-bacterial properties. Hence, this study was done to observe the effect of combinations Keratin-Biocellulose (KBC) with black tamanu oil in diabetic mice ulcers. KBC-black tamanu oil, KBC, and gauze (control) were the treatment variables that were analyzed in this study. Macroscopic visualization, wound
measurement, and histology of the wound were investigated. Results showed that the KBC-black tamanu oil is capable to enhance the wound healing activity in diabetic ulcers with a higher percentage of wound closure and abundant deposition of collagen in the skin tissue. Furthermore, the antibacterial properties of black tamanu oil were assessed through miles misra, demonstrated to act against the gram-positive bacteria. Therefore, KBC-Black tamanu oil has the potential to accelerate the wound healing process.

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Availability

Detail Information

Series Title

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Call Number

BM 23-020

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Wound healing
diabetic ulcer
Black Tamanu Oil
In-Vivo
Keratin-Biocellulose

Specific Detail Info

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Statement of Responsibility

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