Proceedings

Investigation In The Role of Lamin B1 In The Development ofKidney Glomerulus

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Lamins are the major component of nuclear lamina that have roles in several cellular processes, such as cell proliferation and cell survival. Especially lamin B1, which plays a role in maintaining mechanical support of the nucleus, is believed to be essential during embryo development for proper organogenesis. However, previous research has discovered the correlation between age-related kidney dysfunctions and lamin B1 decrease in aged podocytes. Nevertheless, the mechanism of how lamin B1 loss can cause renal dysfunction remains unknown. Thus, to understand this, a deep understanding of the fundamental function of lamin B1 in kidney development is needed. It is achieved by eradicating lamin B1 at a very early stage of glomerulus development. Our result found that specifically knockout lamin B1 in the kidney results in the glomerulus still can develop normally. Thus it suggested that lamin B1 might be essential in the development of other organs, but it was found to be not essential in the development of the kidney. Although, due to the loss of lamin B1, as their mechanical support, the glomerulus might become more fragile and more susceptible to encountering phenotypical changes and damage in the presence of a stressor.

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Detail Information

Series Title

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Call Number

BM 23-028

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Kidney
Glomerulus
Lamin
Lamin B1
Development

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