In Silico Study of Plant Bioactive Compound of Coriandrum Sativum Against Gaba a Receptor | Indonesia International Institute for Life Sciences

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In Silico Study of Plant Bioactive Compound of Coriandrum Sativum Against Gaba a Receptor

Putri Gabriella Angel Natalia Satya - Personal Name;

Cognitive impairments in thinking are the example of neurodegenerative diseases that happened in Alzheimer Disease (AD). Short memory loss (dementia) is one of the symptoms, showed by 60-70% cases found and gradually progress in declination of thinking. Therefore, dementia usually is associated in AD. Lately, an inhibitory neurotransmitter called GABA is known for its relation with working memory (WM) in the healthy young population. This opens research opportunities to learn more about GABA and AD. Moreover, the absences of AD cure becoming goals of every neurodegenerative research. Currently, only two class of drugs that has been approved to relieve the symptoms and increase lifespan of the AD patient. This study aims to find the potential bioactive compounds from Coriandrum sativum plant using in silico method. GABAA Receptor (4COF) will become a target in this study and 50 bioactive compounds will be observed using bioinformatics analytics skill that composed of QSAR method, molecular docking, pharmacokinetics study and molecular dynamics to observe the bioactive compound. It resulted from the total of 50 bioactive, there are 17 compounds that have higher score from standard compound and the highest three are limone, B-Carotenes and B-Sitosterol. The top three compounds have undergoes the pharmacokinetics study and molecular dynamics. For molecular dynamics, the top three compounds have the peak of RMSF around 1-5 Å. Meanwhile, the Benzodiazepine compound has fluctuation of 1- 4.4 Å. To conclude the CS bioactive compounds might has a potential to have a further study to be a potential AD drug.

Availability

4th Floor-i3L Library (EP Report) EP BI004

EP23085

Available - Language

Detail Information

Series Title: -
Call Number: EP BI004
Publisher: i3L, Jakarta : i3L, Jakarta., 2023
Collation: -
Language: English
ISBN/ISSN: -
Classification: NONE
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): Molecular Docking
Coriandrum sativum
GABA Type A Receptor
GABAA Agonist
Alzheimer Disease
Molecular Dynamics
Specific Detail Info: -
Statement of Responsibility: -

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