Proceedings

Cytotoxicity Test for Zn-Sr Cosubstituted Hydroxyapatite

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The current report states the author’s experience as an intern at Badan Riset Inovasi dan Nasional (BRIN), under the department of Pusat Riset Material Maju (PRMM). The goal of this internship was to create a systematic review that discusses the cytotoxic effects of hydroxyapatite cosubstituted with zinc (Zn) and strontium (Sr) on osteoblastic cell lines, with the goal of possibly using this material for bone grafting. The search of articles was conducted through PubMed, ResearchGate, and Wiley Online Library, revealing 118 articles. Out of 118 articles found, only 2 articles met the inclusion criteria and were thus eligible for analysis. These articles were assessed and showed that Zn-Sr cosubstituted hydroxyapatite does not show any cytotoxic activity towards osteoblastic cell lines, and in general shows a higher cell viability compared to simply hydroxyapatite. However, due to the limited number of studies done, further research is required to ensure that Zn-Sr hydroxyapatite is indeed a suitable bone graft material.

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Availability

Detail Information

Series Title

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Call Number

BM 23-005

Publisher

i3L, Jakarta : i3L, Jakarta., 2023

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Cytotoxicity
hydroxyapatite
zinc
strontium
cosubstituted
codoped

Specific Detail Info

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Statement of Responsibility

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Other version/related

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