Proceedings

Mechanotransduction Signaling in Abdominal Aortic Aneurysm: The Role of Endothelial and Smooth Muscle Cells Mechanosensors

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The alteration of mechanical and frictional forces composed of pulsatile and shear stress in the aorta is postulated to play a significant role in the abdominal aortic Aneurysm (AAA) pathogenesis. Accordingly, cumulative evidence was gathered to investigate the mechanicalcues, which were believed to have a role in triggering a cascade of signaling events during the shear-induced AAA development. In this project, the current understandingof the mechanotransduction networks in AAA is summarized, which focuses on identifyng different mechanosensors and stressors presentat the insightsof the mechanotransduction cascades the contribute to the hallmarks of AAA - matrix degradation and loss SMCs - were investigated with the hope of manipulating the mechanomachinery to stop the aneurysm growth. Additionally, whis review highlights the current apporach of AAA treatment along with its potential to reserve its pathological state in reducing the risk of the life-threatening aortic rupture.

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Detail Information

Series Title

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Call Number

BM047

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

BM047

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Abdominal Aortic Aneurysm
Shear Stress
Mechanotransduction
Mechanosensors
Endothelial Cells
Smooth Muscle Cells
Matrix Degradation

Specific Detail Info

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Statement of Responsibility

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