Proceedings

SYSTEMATIC REVIEW AND HISTOLOGICAL INVESTIGATION ON FETAL DEVELOPMENT FOLLOWING GESTATIONAL EXPOSURE TO BISPHENOL S

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The growing awareness ofthe hazard of Bisphenol A has sparked a massive switch to its analog,
Bisphenol S (BPS), which is deemed to be safer. However, the safety of this chemical is questionable
as BPS shares considerable structural similarities with BPA and little scientific evidence backing up its
safety.
This thesis project was conducted to investigate the developmental effects, particularly on
neurodevelopment, following maternal exposure to BPS through a systematic review and an in vivo
experimental study.
The systematic review was conducted based on the guidelines issued by the Office of Health
Assessment and Translation (OHAT) protocol and Preferred Reporting Items for Systematic Review and
Meta-Analysis (PRISMA) for reporting. Meanwhile, for the experimental study, pregnant mice were fed
daily with 500 µg/kg body weight of BPS since E0. Meanwhile, control mice received corn oil as a
vehicle. The brains of the litter were extracted on E16.5 or P1 and processed for hematoxylin & eosin
staining. Following the staining, the morphological appearance and thickness of the cerebral cortex
along with its layers were evaluated.
The systematic review revealed that maternal exposure to BPS is “suspected” for
neurodevelopmental and prenatal developmental disorders while being “not classifiable” for postnatal
developmental disorders. The in vivo study revealed a significant decrease in the cortical layer of BPSexposed mice at both E16.5 and P1. The proportion of the ventricular and subventricular zone was
significantly thicker in BPS-exposed mice at E16.5 while the proportion of subplate and Layer V were
significantly reduced, indicating persisting neurodevelopmental toxicity.

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Availability

Detail Information

Series Title

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Call Number

BM 21-001

Publisher

i3L, Jakarta : i3L, Jakarta., 2021

Collation

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Language

English

ISBN/ISSN

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Classification

BM 21-001

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Bisphenol A
Bisphenol S
OHAT
SYSTEMATIC REVIEW BPS

Specific Detail Info

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Statement of Responsibility

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