Report

Investigation Of Quercetin And Pantoea Agglomerans Exopolysaccharides Direct Combination To Induce Anti-cancer Potential Towards Chemoresistant Colorectal Cancer Cells

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Globally, colorectal cancer remains the third most common cancer to be diagnosed. Nonetheless,
there are current therapies for colorectal cancer, including radiotherapy, chemotherapy, and surgery.
Unfortunately, overuse of chemotherapy can lead to chemoresistance to specific chemotherapeutic
agents. For instance, late-stage colorectal cancer is treated with oxaliplatin. On the other hand,
overuse of these drugs may result in colorectal cancer cells resistant to oxaliplatin. Fortunately, some
substances could solve this issue, namely quercetin and levan. In this research, the methodology
used is cell viability assay by MTT towards HCT116, a software to determine the synergistic effect for
the drug combinations, cell cycle, and apoptosis analysis using flowcytometry to detect the staining
molecule as well as western blot. It turns out quercetin and levan show a synergistic effect and
improve cell death compared to the control as well as quercetin, it modulates the function of p53,
cleavage of PARP, and a possible cleavage of caspase-3
keywords: exopolysaccharides, plant flavonoids chemoresistance,colorectal cancer

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Availability

Detail Information

Series Title

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Call Number

EP BM-013

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

EP BM-013

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

colorectal cancer
exopolysaccharides
plant flavonids chemoresistance

Specific Detail Info

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Statement of Responsibility

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