Thesis

Transcriptional Profiling of Malaria-exposed Mosquitoes: a Comparative Analysis between High and Low Oocyst Density

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Malaria, caused by Plasmodium parasites and transmitted by Anopheles mosquitoes, is a significant
public health issue, particularly in South and Southeast Asia where Plasmodium vivax is prevalent.
Understanding the genetic factors influencing mosquito susceptibility to P. vivax is crucial for
developing targeted malaria control and eradication strategies. Building on previous findings that
equally treated mosquitoes produce distinct oocyst density formations, this study aimed to
investigate the transcriptomic profiles of Anopheles dirus mosquitoes with varying oocyst densities.
Utilizing RNA sequencing, the gene expression profiles of mosquitoes with high and low oocyst
densities were compared. The analysis identified 1,567 differentially expressed genes involved in
various biological processes, including metabolic activities and RNA binding. Notably, mosquitoes
with high oocyst densities exhibited upregulation of genes related to these functions. The findings
highlight significant transcriptional differences that may influence mosquito susceptibility to P. vivax,
pointing to potential molecular targets for intervention. These results emphasize the importance of
genetic factors in malaria transmission dynamics and suggest avenues for further research to explore
genetic manipulation or other strategies to reduce mosquito susceptibility to malaria, thereby
contributing to more effective malaria control measures.

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Availability

Detail Information

Series Title

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Call Number

BM 24-021

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Anopheles dirus
Plasmodium vivax
Transcriptomics
Differential Expressed Gene

Specific Detail Info

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Statement of Responsibility

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