Thesis

Assessing The Cytotoxic Effect of Capsicum annuum extract on Cervical Cancer

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Capsicum annuum, or chili pepper, is known from traditional medicine to have anti-tumor properties.
Recent researches isolated to compound responsible to be Capsaicin, with few researches opposing
this notion. Since there are some disagreements as to the validity of this claim, it is important that
further tests need to be conducted to prove or disprove the point. Hence, this thesis aimed to assess
the cytotoxicity of Capsicum annuum extract toward cancers, with tumor type less picked by most
researches, which is cervical cancer. Molecular docking was used to confirm binding affinity. Extraction
was performed, which then proceed to culturing HeLa cells. The treatment and MTS Assay was
conducted, alongside UV-Vis Quantification. The result showed a slight increase in cell viability in the
lower concentrations, and then steep decline at a certain concentration. It was determined that
Capsaicin would only start to affect the cells at a certain concentration.

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Availability

Detail Information

Series Title

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Call Number

BM 24-003

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Cytotoxicity
cervical cancer
Capsaicin
Capsicum annum extract
Anti-tumor properties

Specific Detail Info

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Statement of Responsibility

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