Thesis

Investigation Of Antioxidant, Anti-Inflammatory, Antibacterial Properties And Phytochemical Screening Of Leaves And Endocarp Extracts Of Elaeocarpus Grandiflorus

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Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals.
Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals
utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal
inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantify the
phytochemical composition of the methanolic extracts of E. grandiflorus leaves and endocarp, as well
as their antibacterial, antioxidant, and anti-inflammatory activity. The findings of this study showed
that the leaves contain more phenolics and flavonoids while endocarp have a higher tannin content.
Moreover, compound isolation from the endocarp yielded six compounds, with three elucidated as
vanillin (2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (3), and
threo-guaiacylglycerol-β-coniferyl aldehyde ether (4). Subsequent HPLC analysis identified and
evaluated the relative amount of gallic acid, compounds 1, 2, 3, 4, and kaempferol in the endocarp.
Interestingly, gallic acid, geraniin, kaempferol and compound 1 were present in the leaves. The
bioactivity assay demonstrated that the leaves exhibit a higher antioxidant and antibacterial activity
which might be attributed to the presence of gallic acid and geraniin. Nevertheless, current findings
warrants further investigation especially in compounds isolation and bioactivity assessment to fully
explore the health benefits of E. grandiflorus extracts.

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Availability

Detail Information

Series Title

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Call Number

BM 24-006

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Bioactivity
phytochemicals
Elaeocarpus grandiflorus
crude extract
leaves
endocarp

Specific Detail Info

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Statement of Responsibility

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