Report

Systematic Review: Medicinal Plant Extract That Exerts Both Antibiofilm and Wound Healing Activity in In Vitro and/or In Vivo Studies

---

The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for
example the formation of wounds due to outer layer damage, it may increase the likelihood of
contraction skin infection, which is a global burden. When open wounds are in contact with
microorganisms, it allows attachment and proliferation, resulting in the development of biofilms.
Antibiotics are usually the first-line treatments when addressing wounds, however, with the
increasing amount of resistant-strain bacteria developing, treatment became more difficult.
Medicinal plants are known to contain phytochemical constituents that exert therapeutic and
pharmacological effects. This systematic review aims to evaluate studies on medicinal plants that
have exerted both antibiofilm and wound healing activities with their phytochemical constituents in
In Vitro and/or In Vivo models. A total of 2,686 publications were identified between 2013 and 2023,
where only five publications (0.18%) passed the rigorous inclusion and exclusion criteria, yielding data
of five plant species that examined a total of 41 MIC values against Pseudomonas aeruginosa (26.8%),
Escherichia coli (17.1%), Staphylococcus aureus (12.2%), Staphylococcus lugdunensis (9.8%), MRSA
(17.1%), and MDR-Pseudomonas aeruginosa (17.1%). Four out of the five studies utilized In Vivo
wound models, including infection-induced, linear, or circular excision models, whereas only one
utilized wound scratch assay (In Vitro) to assess wound healing activity. The medicinal plants include
Buchanania lanzan, Capsicum annuum, Sanguisorba officinalis, Paeonia tenuifolia, and Achillea
fragrantissima, where 40% were extracted for their aerial parts, 40% were extracted for their roots,
and 20% whole plant extract utilizing methanolic, ethanolic, and aqueous extraction type. This review
allows current understanding of antibiofilm and wound healing activity from medicinal plants.

---

Availability

Detail Information

Series Title

-

Call Number

EP BM-040

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Wound healing
Medicinal Plant
Antibofilm
PhytochemicalOR Phytochemistry

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment