Enrichment Program

Innovative Approach On Using Ultrasonic Indirect Cleaning Method To Assist Upstream Production Division Process In Pt. Kalbio Global Medika.

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The upstream division of KGM uses a manual cleaning process for machine parts, which is time-
consuming and inefficient. To address this issue, an innovative approach called indirect ultrasonic
cleaning is proposed. Indirect ultrasonic cleaning uses powerful sound waves at a high frequency to
remove unwanted substances from surfaces immersed in a liquid. Ultrasonic cleaning involves the
forceful collapse of cavitation bubbles, which are formed by sound waves of significant strength. The
typical frequency range for ultrasonic cleaning is around 20 to 200 kHz. Indirect ultrasonic cleaning is
a cost-effective and efficient method for cleaning small items or instruments. It involves using a glass
cup or other container to separate items from cleaning water, ensuring only the inside of the glass cup
becomes contaminated. The method is safer for delicate items and allows for high concentrations of
cleaning chemicals. The study aims to develop a comprehensive protocol for a cleaning validation trial,
focusing on reducing the time required for manual cleaning by using the Indirect Ultrasonic cleaning
technique. The research questions include the time and temperature parameters used to operate the
Ultrasonic Machine indirectly, whether it is possible to clean machine parts while complying with
cGMP, CPOB, and FDA guidelines, and whether the machine parts will not be harmed in terms of
integrity after being cleaned using the Indirect Ultrasonic Cleaning indirect method. Research shows
that the optimal temperature for indirect ultrasonic cleaning is 80°C with a running time of 2-5
minutes. The best frequency for sanitizing and cleaning contaminants on steel and delicate parts is
40kHz-68kHz.

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Availability

Detail Information

Series Title

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Call Number

EP BT-027

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Protocols
Ultrasonic Cleaning
Optimal Parameters
Indirect Cleaning Method

Specific Detail Info

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Statement of Responsibility

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