Thesis

In Vitro Investigation of Cinnamon-Ethanol Extract Anti-Adipogenic Effect on 3T3-L1 Preadipocytes

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Obesity, a longstanding global food security issue, has increased in Indonesia since the
COVID-19 pandemic due to higher consumption of high-fat, high-sugar foods and more
sedentary activity during quarantine. Prevention of obesity can be achieved from the
molecular phase through treatment with spice extract, like cinnamon, to mouse 3T3-L1
preadipocytes. The bioactive compound present in cinnamon (cinnamaldehyde, cinnamic
acid, eugenol) possesses anti-adipogenic properties that is able to promote growth in 3T3-L1
while inhibiting the process of lipid accumulation in the cells through modulation of certain
molecular pathways. This study aims to evaluate the effect of cinnamon-ethanol extract
(CEE) activity on 3T3-L1 preadipocyte cell viability and lipid accumulation. The results
showed that CEE, in all concentration ranges of 1000, 250, 62.5, and 15.625 μg/mL, can
significantly increase the percentage of cell viability, particularly, the extract produced the
most and least cell viability at 1000 and 15.625 μg/mL, respectively (p < 0.0001 vs. p <
0.031). Furthermore, the CEE concentration at 15.625 μg/mL is able to suppress lipid
accumulation significantly (p < 0.0001) by inhibiting adipogenesis and other
lipid-synthesizing processes.

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Availability

Detail Information

Series Title

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Call Number

FSN 24-012

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

lipid accumulation
obesity
anti-adipogenesis
cell viability
cinnamon-ethanol extract

Specific Detail Info

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Statement of Responsibility

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