Thesis

Cellular Exploration of Potential Synthetic Compounds for Advancing Drug Development in Psoriasis

---

Psoriasis is a prevalent chronic autoimmune inflammatory skin disease affecting over 125 million
individuals globally, posing a significant health challenge. Investigating synthetic compounds featuring
the 1,2,3-triazole structure known for their anti-inflammatory effects, this research aimed to evaluate
synthetic drug compound candidates for their anti-inflammatory properties. The assessmentsinvolved

cytokine production and cytotoxicity assays using human keratinocyte (HaCaT) and macrophage (THP-
1) cell models. The results demonstrated that all the tested synthetic compounds were non-toxic and

capable of effectively inhibiting the expression of IL-6, IL-8, and TNF-α in the inflammation-induced cell
lines. Notably, CCL-7040n stood out by showcasing inhibitory effects towards all three critical cytokines
in the macrophage model, as well as IL-8 in the keratinocyte model. Further research is needed to

elucidate the precise mechanisms of action, evaluate the effects on a broader panel of psoriasis-
relevant cytokines, and validate the therapeutic potential in vivo. Nonetheless, the findings highlighted
the non-toxic and promising anti-inflammatory properties of the 1,2,3-triazole-based synthetic
compounds, positioning them as potential therapeutic candidates for the management of psoriasis.

---

Availability

Detail Information

Series Title

-

Call Number

BT 24-021

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Psoriasis
HaCaT
Synthetic Compound
Cytokine Inhibition
THP-1

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment