Thesis

Electrophysiological Evaluation of the Left-Right Asymmetry of MHb-IPN Pathway in inversus viscerum (iv) Mutant Mouse

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The Medial Habenula-Interpeduncular Nucleus (MHb-IPN) pathway is an emerging with recently
discovered roles in fear memory expression. As ongoing research revealed the asymmetric functions
of this pathway in mammals, questions were asked regarding the developmental origins of this
asymmetry, particularly its relation to the visceral asymmetry. This study set out to investigate the
lateral asymmetry within the medial habenula-interpeduncular nucleus (MHb-IPN) pathway,
specifically its relation to visceral asymmetry, by using patch-clamp electrophysiology in wild-type and
inversus viscerum (iv) mutant mice. The MHb-IPN pathway is a pathway involved in fear memory
processing and has emerging roles in various other functions. Properties such as release probability
and potentiation by GABABR agonist baclofen were measured as a basis for evaluating asymmetry.
Results indicated a trend of higher release probability on the left side in situs solitus, while situs
inversus mice showed slight trends pointing towards a correlation between visceral asymmetry and
MHb-IPN functional asymmetry. Understanding this asymmetry could contribute to understanding and
treating fear-related conditions as well as other possibilities.

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Availability

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Detail Information

Series Title

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Call Number

BM 24-023

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

medial habenula
interpeduncular nucleus
inversus viscerum
patch-clamp

Specific Detail Info

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Statement of Responsibility

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