Thesis

Evaluating the Role of Gene X in Pancreatic Adenocarcinoma (PAAD) Survivability In Vitro

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Pancreatic adenocarcinoma (PAAD) remains a life-threatening disease with the most unfavorable
prognosis among all cancer types. This is mainly due to the high rate of cell survivability marked by
rapid cell proliferation and migration activity. Despite having KRAS oncogene as a known commonly
mutated driver gene, targeting it has been challenging and has hindered the development of effective
drugs for PAAD. Hence, investigating a novel therapeutic target to enhance the prognosis and survival
outcomes of PAAD is urgently needed. A previous in silico study by the Department of Cancer Biology
and Drug Discovery at Taipei Medical University predicted that Gene X contributes to the poor
prognosis of PAAD. Furthermore, our analysis revealed that Gene X correlates with MTFR2, TTK, and
TP53, all of which are known to promote cell survivability by increasing cell proliferation and migration.
Further in vitro analysis was conducted to validate these findings. It has been found that indeed Gene
X contributes to PAAD survivability and is supported by its correlation with MTFR2, TTK, and TP53. The
results also found the inhibition of Gene X reduced cell survivability as evidenced by decreased cell
proliferation and cell migration activity. The findings indicate that Gene X, which is associated with the
MTFR2, TTK, and TP53 genes, plays an important role in enhancing PAAD cell survival. Thus, the role
of Gene X is the potential therapeutic target for PAAD.

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Availability

Detail Information

Series Title

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Call Number

BM 24-029

Publisher

i3L, Jakarta : i3L Press., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

cell migration
PAAD
Gene X
Cell survivability
Cell proliferation

Specific Detail Info

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Statement of Responsibility

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