Thesis

Exploring the Impact of Andaliman (Zanthoxylum acanthopodium) Fruit Crude Extract in Immortalized Human Keratinocyte Cells Anti-Inflammatory Profile.

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This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium
DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of
Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB
signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study
demonstrates a significant reduction of total protein content in Lowery Assay, ELISA TNF-α levels, and
pro-inflammatory gene expression in H2O2-induced inflamed HaCaT cells. These findings provide
compelling evidence for Andaliman's anti-inflammatory potential and highlight the importance of
methodological considerations in natural product research. Future studies addressing the identified
limitations could further elucidate Andaliman's mechanisms of action, optimize its formulation, and
pave the way for its development into a novel, plant-based anti-inflammatory therapeutic.

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Availability

Detail Information

Series Title

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Call Number

BM 24-031

Publisher

i3L, Jakarta : i3L Press., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

HaCaT
Skin
phytochemical
lemon pepper
Inflammatory

Specific Detail Info

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Statement of Responsibility

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