Thesis

Investigation of Anti-Cancer Potentials between Astragaloside IV and Quercetin towards Oxaliplatin-resistant Colorectal Cancer Cell Line

---

Colorectal cancer is the third place cause of death tumor globally. And its frequent prevalence may be
caused by the conventional treatments that has been applied. One of the conventional or commonly
used treatments are chemotherapy, one of colorectal cancer common chemotherapy are oxaliplatin.
This would create drug-resistant cancer. For this effort in counteracting the resistant caused by the
cancer, natural products like quercetin and astragaloside IV was chosen. In this research, the
methodology used is cell viability assay by MTT towards HCT116 and Oxaliplatin-resistant HCT116
(OXARHCT116), compusyn which is a software to determine the synergistic effect for the drug
combinations, and apoptosis analysis using flow cytometry, as well as in silico to elucidate the
mechanism between oxaliplatin-treated and oxaliplatin-resistant cancer cell line. It turns out
quercetin and levan induce an adequate synergistic despite being cytotoxic in normal untreated cell
line, but not as much in terms of OXARHCT116.

---

Availability

Detail Information

Series Title

-

Call Number

BM 24-033

Publisher

i3L, Jakarta : i3L Press., 2024

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

colorectal cancer
Drug Resistance
oxaliplatin
quercetin
astragaloside iv

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment