Thesis

Screening of Isoflavone-Modified Compounds as Potential Therapeutic Agents towards Skin Inflammation Disease in Cellular Level

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inflammation plays a crucial role in the pathogenesis of various skin conditions such as psoriasis and
atopic dermatitis, primarily driven by abnormal cytokine production. This study investigates the
anti-inflammatory potential of several synthetic isoflavone-modified compounds (CYR-6811k, CYR-6812l,
CYR-6813m, CYR-6815o, CYR-6816p) by examining their effects on cytokine production in THP-1 and
HaCaT cells. The selected compounds were evaluated for their ability to inhibit the production of key
cytokines, including IL-6, IL-8, TNF-α, and CXCL1.
The results indicate that the synthetic isoflavone-modified compounds significantly inhibited IL-6 and
IL-8 production in both cell lines, suggesting their potential as therapeutic agents for treating skin
inflammatory diseases. However, their effects on TNF-α and CXCL1 production were less consistent.
These findings underscore the complexity of cytokine modulation and the potential of isoflavone
derivatives in dermatological therapeutics.
Future research should focus on further optimization and testing of these compounds to enhance their
efficacy and understand their broader implications. Recommendations include exploring a broader range
of cytokines, investigating the specific pathways targeted by these compounds, and comparing their
effectiveness with established anti-inflammatory drugs.

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Availability

Detail Information

Series Title

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Call Number

BM 24-038

Publisher

i3L, Jakarta : i3L Press., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Skin inflammation disease
CCK-8 Assay
Cytokine production
Enzyme-Linked Immunosorbent

Specific Detail Info

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Statement of Responsibility

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Other version/related

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