Thesis

Formulation and Evaluation of Gel Facial Wash Containing Combination of Cinnamon Bark Essential Oil (CBEO) and Turmeric Essential Oil (TEO) Against Acne-causing Bacteria

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High cases of side effects such as nose-bleeding and mucosal dryness due to synthetic treatments of
acne lead to the implementation of plant extracts in topical formulations as alternative treatments.
Cinnamon bark essential oil (CBEO) (Cinnamomum burmannii) and Turmeric essential oil (TEO)
(Curcuma Longa) and have proven antibacterial efficacy against acne-causing bacteria,
Staphylococcus aureus, with the action possibly due to the beneficial phytochemical constituents —
trans-cinnamaldehyde (TC) and turmerones present in CBEO and TEO, respectively. However, no
studies have been conducted in evaluating the antibacterial interaction between TEO and CBEO.
With differences in antibacterial mechanisms of actions, a synergistic interaction is likely to occur. By
conducting the checkerboard test and Miles and Misra method, the study result proved partial
synergistic interaction, in terms of both bacteriostatic and bactericidal activity, when CBEO
containing 73.98% TC and TEO containing 34.88% turmerones are used in combination. The
combination extract was then implemented at their combined Minimum Bactericidal Concentration
(MBCs) into three formulations of gel facial with varied coco glucoside (CG) concentrations. Upon
physicochemical and sensory evaluations, all formulations showed acceptable physicochemical
properties. However, only F2 (20% w/w CG) and F3 (30% w/w CG) showed satisfactory consumer
acceptability with F3, a slight translucent gel with yellow tints, being the most preferred. Although
the study proves benefits for use as an anti-acne agent, there are some limitations in this study such
as untested safety of the combination extract at the implemented concentration and a
recommendation includes conducting cytotoxicity assay.

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Availability

Detail Information

Series Title

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Call Number

PHA 24-009

Publisher

i3L, Jakarta : i3L Press., 2025

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Sensory evaluation
antibacterial activity
formulation
Cinnamon Bark Essential Oil
Turmeric Essential Oil
Partial Synergism
Gel Facial Wash

Specific Detail Info

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Statement of Responsibility

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