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In Silico and In Vitro Assessment of Coriandrum sativum Extract Potential for Overcoming Cisplatin Resistance in Non Small Cell Lung Cancer

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Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for 85% of
cases of lung cancer. NSCLC is commonly treated with cisplatin, however, NSCLC develops resistance
to cisplatin via several mechanisms, which reduces treatment efficacy and becomes a major
challenge in its treatment. Several plant extracts have been researched as potential anticancer,
including Coriandrum sativum, which contains many bioactive compounds such as quercetin and has
shown promise in overcoming cisplatin resistance in NSCLC. This research investigates the C.sativum
extract potential to overcome cisplatin resistance NSCLC by employing molecular docking,
drug-likeness, and cytotoxic activity. The C.sativum bioactive compound interacted with important
biomarker proteins involved in cisplatin resistance NSCLC and demonstrated cisplatin resistance
overcoming capability. C.sativum enhances chemosensitivity and reduces resistance mechanisms in
NSCLC which may improve therapeutic outcomes. Further studies are needed to explore the clinical
applicability of these findings.

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Availability

Detail Information

Series Title

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Call Number

EP BM-002

Publisher

i3L, Jakarta : i3L Press., 2025

Collation

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Language

English

ISBN/ISSN

EP078

Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

non-small cell lung cancer
cytotoxic activity

Specific Detail Info

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Statement of Responsibility

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