Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals. Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantif…
The rapid advancement of technology has a big impact on how we live our daily lives. Artificial Intelligence (AI), or more precisely, an AI-powered chatbot, is one of those technologies. This virtual assistant has gained a lot of popularity recently, mostly because of noteworthy advancements in artificial intelligence, machine learning, and other basic fields like neural networks and natural…
The healthcare industry has undergone a remarkable transformation in recent years due to technological advancements and digitalization. To address the need for accessible genomic healthcare information, GNOMED (Genomics Education) has been developed, a web application empowering patients with comprehensive reports from authorized genomic experts. Utilizing a rapid application development (R…
Public health surveillance plays a pivotal role in ending the COVID-19 emergency, especially monitoring the emergence of new lineages. A dynamic SARS-CoV-2 lineage naming system, known as the Pango nomenclature system currently being used to assist genomic epidemiology. Currently, researchers manually draw charts to visualize mutations found in major pango lineages that shape the evolutionar…
In recent years, the cosmetic industry in Indonesia has experienced a sustainable growth due to the emergence of both new local and established brands with strong reputations. Among all, Generation Z represents the predominant demographic shaping the trajectory of the beauty industry in Indonesia. However, the majority of conventional cosmetics have limited regard towards the environmental …
Earthcell is a brand that is planned to be established as a forward-thinking company and aims to align with Sustainable Development Goals specifically for responsible consumption and production (SDG 12), climate action (SDG 13), good health and well-being (SDG 3). The current market offerings are mostly loaded with products that incorporate artificial ingredients, high doses of caffeine, an…
Phylogenetic distance estimation between taxa in a tree is critical for tree reconstruction. There exist several classical methods that are already established in the field of phylogenetics. However, these classical methods of distance estimation are not straightforward and their computation can be tedious. As neural networks show great success in pattern recognition tasks, it is reasonable tha…
Pancreatic cancer (PC) is a highly aggressive malignancy with limited treatment options and poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein is abundantly expressed in PC cells and has been linked to tumor growth and metastasis. This research intends to provide insights into the cytotoxic effect of the CEACAM6-mediated targeted therapy using anti-CEACA…
Clopidogrel is an antiplatelet medication used for treating one of the major contributors of mortality worldwide – cardiovascular diseases (CAVDs). The conventional synthesis of clopidogrel as a complex organic molecule can be time-consuming and costly as various reaction conditions need to be set and maintained. A simpler method following the Multicomponent Reaction (MCR), specifically Ugi-3…
This project aims to evaluate the cleaning capacities of a non-irritant, sulfate free organic dog shampoo. Surfactants play a vital role in shaping product characteristics. Coco glucoside and cocamidopropyl betaine (CAPB) were used as the surfactants of this experiment for its non irritant properties. Additionally, CAPB's amphoteric nature proves valuable in dispersing solid ingredients efficie…
Apis mellifera or honey bee is the most crucial pollinator globally, providing 50% of global crop pollination. However, bee colony loss is increasing and one of the causes is American foulbrood disease (AFB), a disease that kills honey bee larva. Paenibacillus larvae, a gram positive bacteria is the causative agent of AFB, it can produce spores that are able to survive in extreme heat and c…
Hepatocellular carcinoma (HCC) poses a significant challenge in clinical management due to late-stage diagnosis and limited curative interventions. The imperative to develop more efficacious therapeutic approaches for HCC underscores the exploration of oncolytic virotherapy, an innovative treatment modality exhibiting promising antitumor properties. Among potential oncolytic vectors, the measle…
Tankyrase 1 has received attention as a promising target for anti-cancer therapies due to its upregulated expression in various cancer types. Its crucial role in PARsylation leads to the degradation of tumor suppressors (e.g. Axin, TRF1, and PTEN) through the ubiquitin-proteasome pathway, highlighting its significance in oncogenic processes. The urgency to discover novel tankyrase 1 inhibitors …
Exposure to ultraviolet (UV) radiation from the sun can elicit both positive and negative effects on the skin. Among the three types of UV radiation, UVB (280-315 nm) is particularly detrimental, causing sunburns, skin cancer, and premature aging. Furthermore, UV exposure induces the generation of reactive oxygen species (ROS), which the skin recognizes as external ROS. This study investigates …