This book addresses clearly and objectively the fundamental and technological concepts involved in the process and manufacturing of high-quality herbal products. The text is written using a multidisciplinary approach to include all subjects involved in phytopharmaceutical technology, and to accurately portray each step of the process
Neutrophils are the main cells that play a significant role in the innate immune system. Upon a pathogenic invasion, these cells are recruited to the site of infection and perform many different functions. Targeting the neutrophils for therapeutic interventions has been a great challenge due to the complexity of their signaling pathway and mechanisms. Therefore, the search for drug candidates t…
Tuberculosis caused by an obligate aerobic bacteria known as Mycobacterium tuberculosis is one of the most lifelong diseases that has been infecting humans worldwide; Indonesia is one of the countries that has the highest prevalence of tuberculosis. The bacteria itself possesses an atypical cell wall structure that protects them from harmful drugs. With the inconsistent, prolonged drug treatmen…
Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric CNS tumor yet lacking standardized therapies while current management standards are not of significant clinical benefit. With the opportunity of accessing the Childhood Cancer Model Atlas (CCMA)’s vast pediatric cancer resources, high-throughput drug screening (HTS) was carried out on the CCMA’s ATRT cohort against the novel…
Enterobacter bugandensis belongs to the ESKAPE bacteria, a group notorious for being prominent causative agents of hospital-acquired infections. Despite being a recent discovery in 2016, E. bugandensis is an emerging pathogen that has been responsible for several bacteremia outbreaks. Notably, E. bugandensis possesses high levels of multidrug resistance and little is known about its pathogenesi…
The current report describes the experience that the author gained during her 11 months of internship placement at Indonesia International Institute for Life Sciences (i3L). The internship was organized by Ms. Elizabeth Sidhartha, B.Sc., M.Sc. (a Biomedicine faculty) and was conducted online. The goal of this internship is to produce a systematic review discussing the potential of Plasmodium fa…
Psoriasis is an autoimmune skin disorder that has impacted the global population from children to adults. Psoriasis is characterized by unusual proliferation of keratinocytes, leading to itchy, bleeding, scaly, and red lesions due to increased immune system activity. Existing topical treatments often result in side effects, emphasizing the necessity for advanced drug discovery in managing psori…
Triple negative breast cancer is a subtypes of breast cancer that are known to have a bad prognosis and spread faster. TNBC tends to have bad prognosis due to the absence of the ER, PR, and HER receptors on the surface of the cells. These absent of receptor cause a limitation for treating them, Additionally, several drugs were proposed as a treatment for TNBC but administration of a single drug…
Acute myeloid leukemia (AML) is a heterogenous blood cancer disease that develops from the stem cell precursors which the myeloid lineage happened due to genetic lesion that leads to overproduction and failure to differentiate these myeloid blast cells. A mutation in the FMS-like tyrosine kinase 3 (FLT3) gene, is the most frequent genetic lesion in AML patients, this mutation is linked with a p…
Development of Drugs provide specific information on drug targets, mechanism, and interaction with other drugs. This information is important in order to prevent adverse drug reactions when prescribing more than 1 drugs. Electonic databases like Drugbank provide stotrage and access of this information to the public mass. However, not all drug databases are freely available making it hard to aut…
Mass Drug Administration is one of the strategy use by countries to intervene the progression of helminth infection. The goal of MDA program is to give preventive chemotherapy to a populations by using broad spectrum anti-helminthic drugs. The drugs were administered by the people once or twice a year depending on the prevalence of their region. The Indonesian government has applied this …
Cosmetics have been widely used to improve the skin condition. Niacinamide is known as the vitamin B3 which works to repair the skin condition. Unfortunately, It has a limited ability to penetrate the skin. Therefore, a penetration enhancers is important to be conducted to ensure an adequate activity of the active ingredients. Several types of glycols were tested and expected that the differ…
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virulent source of the COVID-19 disease. As a result of the rapid transmission of the viral agent and deficiency of specific drugs against the virus, a worldwide pandemic ensued with a terrifying death toll. Thus there is tremendous urgency to discover substances for the development of specific COVID-19 drugs. With in…
The ease of access to food in our era has come with a risk of unhealthy lifestyle, giving rise to numerous health problems, including colorectal cancer (CRC). However, the development of cancer chemotherapy has been outpaced by the swift growth of CRC prevalence. The harsh side effects still become the primary reason for the low patient compliance, which may be minimized by limiting the drug ac…
Colorectal cancer (CRC) still becomes the second leading cause of global cancer-related mortalities, despite the advances in diagnosis and treatment. Chemotherapeutic drugs, such as 5- fluorouracil (5-FU), still becomes the main treatment modalities for CRC, despite its rapid elimination rate and diverse adverse reactions. Recently, strategies to establish targeted drug delivery systems for the…
Schizophrenia is a disease that could be considered of low prevalence, yet it elicits a high disease burden. The main treatment that are offered to help alleviate the symptoms and cure the schizophrenia would normally comprise of the utilization of antipsychotics. Unfortunately, the use of antipsychotics could lead to the manifestation of unwanted adverse drug reactions. However, this manifesta…
Combinatorial therapy might be the solution for the rising incidence of CRC around the world. By combining multiple anti-cancer drug, a more effective cancer killing ability might be produced at lower dosage and toxicities. As a potential anti-cancer sources, ethyl acetate extract of soursop leaves (EEAM) has been reported to work against HT-29 CRC cell line. The mechanism in which it may works…
Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamen…
"Focuses on important topics for the consulting pharmacologist, including prescription, over-the-counter and illegal drugs and their effects on criminal and civil proceedings Details the "how-to" aspects of being an expert witness in pharmacology by presenting real-life cases and effective tips and experiences Includes several appendices, such as a sample letter of engagement and fee schedule, …
Drug Delivery Aspects: Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, and scale-up of nano and micro carriers. Various aspects like conversion of micro-nano particles into solid dosage form, large scale industry manufacturing challenges of nanocarriers, regulatory considerations on drug device combinations are featured in this volume.…
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics …
This book examines the laws and regulations relating to the practice of the pharmacy and the regulation and control of drugs.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the proc…
Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provid…
Goodman & Gilman's The Manual of Pharmacology and Therapeutics offers concise, authoritative coverage of class-specific and disease-specific drugs, organized primarily by organ/system. Derived from Goodman & Gilman's Pharmacological Basis of Therapeutics, Twelfth Edition and further updated, this streamlined text focuses on the principles of medical pharmacology and drug therapy and delivers co…