substantial global public health concern has been raised due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in 2019. Flavonoids were reported to possess anti-SARS-CoV-2 properties by targeting 3-Chymotrypsin Like protease (3CLpro) which is the main enzyme involved in the life cycle of SARS-CoV-2. Zingiber zerumbet (bitter ginger) is a plant native to Indonesia …
The COVID-19 pandemic began in late 2019, when a cluster of patients began to experience shortness of breath and fever. This disease became a world pandemic by March 2020. The internship project focused on designing a plasmid to express the 3CLpro protein from the virus SARS-COV-2 in order to aid in a larger project that aims to research flavonoid compounds that inhibit the function of 3CLpro. …
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virulent source of the COVID-19 disease. As a result of the rapid transmission of the viral agent and deficiency of specific drugs against the virus, a worldwide pandemic ensued with a terrifying death toll. Thus there is tremendous urgency to discover substances for the development of specific COVID-19 drugs. With in…
The emergence of a new human betacoronavirus strain called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the causative agent of CoronaVirus Disease 19 (COVID-19) has caused a pandemic. According to previous experiments, it is known that the 3C-like protease of SARS-CoV-2 plays an important role in the pathogenicity of the virus. Flavonoids are a group of natural substances bel…