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Found 2 from your keywords: subject="ATF4"
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eIF2α-ATF4 Signaling Mediates NASH Progression through Suppression of Kupffe…
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Ellen Budiono

Nonalcoholic steatohepatitis (NASH) is a complex liver condition marked by hepatic steatosis, injury, inflammation, and fibrosis. It is often triggered by obesity-induced ER stress which activates the integrated stress response (ISR) pathway. This pathway, involving eIF2α and ATF4, contributes to NASH progression, particularly fibrosis via hepatic stellate cells (HSCs) activation. However, …

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BM 24-015
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Role of Integrated Stress Response in Mediating Mitochondrial Unfolded Protei…
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Richie Justin

The integrated stress response (ISR) is one of the most conserved cellular stress responses during mitochondrial dysfunction. The keys in the activation of ISR are the phosphorylation of eIF2α and subsequent induction of ATF4. The phosphorylation of eIF2α is caused by the activation of four specific serine/threonine kinases, which are Heme Regulated Inhibitor (HRI), Protein Kinase Ribonucleic…

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BM 23-034