Acute myeloid leukemia (AML) is a heterogenous blood cancer disease that develops from the stem cell precursors which the myeloid lineage happened due to genetic lesion that leads to overproduction and failure to differentiate these myeloid blast cells. A mutation in the FMS-like tyrosine kinase 3 (FLT3) gene, is the most frequent genetic lesion in AML patients, this mutation is linked with a p…
Acute myeloid leukemia (AML) is a type of blood cancer that develops due to DNA mutations in the stem cells. AML survival rates show only 30.5% which significantly contributes to the number of cancer-related mortality. One of the altered genes that are frequently identified in AML patients is CEBPA. The CEBPA gene encodes the C/EBPɑ-p42 and C/EBPɑ-p30 that consist of C-terminal and N-termi…